Using published literature to find causal relationships that can be connected to lead to a new causal relationship

In abstract this approach systematically discovers one paper that says “A -> B” and one paper that says “B ->m C” and connects them to say “A -> C”

This is the approach in Undiscovered Public Knowledge (Paper) where they discovered that fish oil (A) affected blood viscosity (B) and blood viscosity affected Reynauds disease.

This is also the approach used by the Big Mechanism Program. It successfully found a new mechanism for cancer Large-scale automated machine reading discovers new cancer-driving mechanisms and was commercialized into Lum.ai

IBM Watson attempted to use this method but

This is also the approach for Data-Driven Discovery of Models (D3M)

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